What Exactly is Entourage Effect? Well, it’s a very interesting and natural phenomenon that occurs in cannabis on a chemical compound level. It’s a bit complicated and scientific. But its fascinating. So we will break it down into layman’s terms for you and see if we can make sense of it all. Basically, the Entourage Effect is a cannabinoid system modulator. It means the compounds not only affect you, but they also affect each other. It’s pretty cool science.

What Exactly is Entourage Effect?

When I hear the word entourage I think of the great series on HBO of a movie star and his group of pals living the dream. The word also conjures up images of Led Zeppelin entering a room with their groupies and crew and media guys. That is what an entourage is. Its the group that surrounds travels with and thrives off a central figure like a Rock Band, a movie star or, in this case, a chemical compound.

That Rock Star compound is known as THC, (or tetrahydrocannabinol.) This THC is the psychoactive compound that gets you high. It has recently been discovered that our little friend THC has a few friends of his own. These are the other chemical compounds found in cannabis. And these guys, it turns out, has an effect, a sort of peer pressure, on our friend THC. I guess you could call this group of other chemical compounds THC’s entourage.

Hanging Out With My Boys

You may be familiar with expressions such as, “You are what you eat?” Or “Show me your friends and I will show you yourself.” These are age-old adages for a reason. They’re true. The same holds true with chemical compounds that hang around together. They rub off on each other, literally. The entourage effect refers to the chemical compounds which hang around THC, the psychotropic, and although having no psychotropic properties themselves, affect the THC. They modulate the overall effects of the actual psychotropic.

It reminds me of the Chicago Bulls when they had Michael Jordan. His entire team is going into the Basketball Hall of Fame. Remember Scotty Pippen? or Dennis Rodman? These guys were really good players. But the star was Michael Jordan. He raised the level of their game. He created opportunities that would otherwise not have existed for them to thrive. The same holds true for the New England Patriots. Tom Brady has been to 8 Super Bowls. His superstar prowess carries a team of 100 guys. The same holds true in cannabis. THC is the star. His supporting cast aides and abets. All are uplifted. And the entire effect is magnified and modified due to the entourage.

How Does The Entourage Effect THC?

Firstly, it should be noted that the Entourage Effect started as mere conjecture and anecdote. However, the proof is in the pudding and taking hold in scientific circles. Formidable scientists and doctors like Raphael Mechoulam, and S. Ben Shabat have done remarkable work in this field of research. Shabat actually introduced the phrase as far back as 1998. They realized that cannabinoids have a molecular regulation route, meaning they work in harmony in a concert of delicate modulations. This enhancement or modulation of the THC was recognized by Shabat who called it, “the sum of all the parts that leads to the magic or power of cannabis.

THC has a best buddy named CBD. CBD is the second biggest player in the chemical compound entourage. However, CBD is completely non-psychoactive. This does not, however, mean it doesn’t have an effect. It does. For example, THC gets you high and causes short-term memory loss. CBD actually counters that negative side effect. Then there is THC’s younger brother, myrcene. Myrcene has sedative effects when in cahoots with THC. This is apparent in Indica strains. Myrcene is responsible for couch locking.

Then there’s Linalool. This wicked stepchild modulates the neurotransmitters and produces anxiolytic and sedative effects. Then there’s Chris Emerson’s research which revealed even more cannabinoids. His research shows that terpenoids and flavonoids contribute to clinical cannabis effects. And the reason stated in his synopsis is “the entourage effect.” And the list goes on. THC has a large and regal entourage. And now we know how they affect the star. A Star is Born, and it’s not Lady Gaga.